Immunoglobulin E, Interleukin-18 and Interleukin-12 in Patients with Atopic Dermatitis: Correlation
with Disease Activity
Published: April 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.5742
Khaled Zedan, Zafar Rasheed, Yaser Farouk, Abdullateef A. Alzolibani,
Ghada Bin Saif, Hisham A. Ismail, Ahmad A. Al Robaee
1. Assistant Professor, Department of Pediatrics, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
2. Assistant Professor, Department of Medical Biochemistry, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
3. Assistant Professor, Department of Pediatrics, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
4. Associate Professor, Department of Dermatology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
5. Associate Professor, Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
6. Professor, Department of Pathology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
7. Professor, Department of Dermatology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Correspondence
Dr. Zafar Rasheed,
Assistant Professor, Department of Medical Biochemistry, College of Medicine, Qassim University,
P.O. Box 30109, Buraidah 51452, Saudi Arabia.
E-mail: zafarrasheed@qumed.edu.sa
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Immunological/inflammatory reactions are reported to play a role in AD but their role in disease activity has not been fully investigated. This study was done to investigate the role of immunoglobulin E (IgE), interleukin (IL)-18 and IL-12 in AD patients with different disease severities.
Materials and Methods: Sera from 50 AD infants with varying levels of disease activity according to the scoring index of atopic dermatitis (SCORAD) index and 30 age-matched healthy controls were evaluated for serum levels of IgE, IL-18 and IL-12/p40.
Results: Serum analysis showed higher levels of IgE, IL-18 or IL-12/p40 in AD patients compared with controls. Interestingly, not only was there an increased number of subjects positive for IgE, IL-18 or IL-12/p40, but also the levels of these parameters were higher among AD patients whose SCORAD scores were higher. In addition, a significant correlation was observed between the levels of these parameters and SCORAD scores.
Conclusion: These findings support an association between IgE, IL-18 or IL-12/p40 and AD. The stronger response observed in serum samples from patients with higher SCORAD scores suggest that IgE, IL-18 and IL-12/p40 may be useful in evaluating the progression of AD and in elucidating the mechanisms of disease pathogenesis.
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